Best US Open Tennis Men's Betting Picks

There's plenty of headlines on the men's draw entering this year's US Open. Novak Djokovic, in search of a record-tying 23rd Grand Slam, is likely ineligible to play because of his vaccination status, while Rafael Nadal could pad his lead in that category.

Daniil Medvedev, who was ineligible to play at Wimbledon due to being Russian, is looking to defend his 2021 US Open title but will face challenges from players like Nick Kyrgios, Carlos Alcaraz, and Jannik Sinner.

Outright Betting Odds

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Novak Djokovic +150

Daniil Medvedev +225

Carlos Alcaraz +350

Rafael Nadal +500

Nick Kyrgios +700

Jannik Sinner +1400

Stefanos Tsitsipas +1400

Alexander Zverev +1600

Felix Auger Aliassime +2000

Matteo Berrettini +2000

No-No for Novak

Novak Djokovic's stance on the COVID-19 vaccine and body autonomy has been well documented, as has the US government's stance that foreign travelers need to be vaccinated to enter the country. Neither of those appear to be changing ahead of the US Open, so don't expect Djokovic to be there, despite the fact he's still the betting favorite.

However, there's a slight hope for Djokovic. Some fans are suggesting an exception may be made, especially since the US Open website, on Monday, posted this note about fans: "At this time, ticket holders will not be required to show proof of COVID vaccination for admission into the US Open."

If he's somehow able to play, Djokovic will likely win the tournament. He won Wimbledon and is in pursuit of tying Rafael Nadal for the most Grand Slam victories of all time.

Kyrgios on the Rise

Nick Kyrgios (+700) has seen his odds of winning the US Open shrink considerably since his performance at Wimbledon, and deservedly so. The talented and enigmatic Aussie reached his first Grand Slam final at Wimbledon, playing with a level of confidence we haven't seen from him in recent memory.

Since then, Kyrgios won the Citi Open and reached the quarter-final at the Canadian Open, defeating world No. 1 Daniil Medvedev in the Round of 32. The world No. 26 is an impressive 31-9 this season and is poised to do some damage at the US Open. Here's hoping he matches up against Stefanos Tsitsipas, who took issue with Kyrgios in their Wimbledon matchup earlier this season.

Future on Display

Beyond Djokovic, Kyrgios, and perhaps world No. 1 Medvedev, this year's US Open feels like it could belong to the future generation of young tennis stars, specifically Carlos Alcaraz (+350) and Jannik Sinner (+1400).

Alcaraz has had mixed results as of late, but the 19-year-old Spaniard has been compared to Rafael Nadal and excels on clay and hard courts. He's a dynamic player who feeds off the crowd and should be a fan favorite in New York.

Sinner, meanwhile, has struggled a bit as of late. The 21-year-old Italian lost to Felix Auger-Aliassime in the Round of 16 at the Cincinnati Masters and lost in the Round of 16 at the Canadian Open. Before that, however, he won the Croatia Open. Sinner also has Alcaraz's number, beating the Spaniard in each of their last two matches in what could become the next great rivalry on the ATP Tour.

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