Today in the MLB: July 22, 2025 Best Bets, Odds, Lines, and More

Baltimore Orioles (+123) @ Cleveland Guardians (-152):

Spread: Cleveland Guardians -1.5 Over/Under: 8.5

Pitching Matchup: Brandon Young (7.52 ERA) VS Joey Cantillo (4.17 ERA)

Detroit Tigers (-139) @ Pittsburgh Pirates (+112):

Spread: Detroit Tigers -1.5 Over/Under: 8.0

Pitching Matchup: Casey Mize (3.15 ERA) VS Mitch Keller (3.48 ERA) 

San Diego Padres (-104) @ Miami Marlins (-121):

Spread: San Diego Padres -1.5 Over/Under: 8

Pitching Matchup: Stephen Kolek (4.24 ERA) VS Edward Cabrera (3.61 ERA)

Boston Red Sox (+170) @ Philadelphia Phillies (-230):

Spread: Philadelphia Phillies -1.5 Over/Under: 8.5

Pitching Matchup: Richard Fitts (4.28 ERA) VS Cristopher Sánchez (2.50 ERA)

Cincinnati Reds (-137) @ Washington Nationals (+112):

Spread: Cincinnati Reds -1.5 Over/Under: 8.5

Pitching Matchup: Chase Burns (6.19 ERA) VS Brad Lord (3.46 ERA)

New York Yankees (+102) @ Toronto Blue Jays (-127):

Spread: Toronto Blue Jays -1.5 Over/Under: 9.0

Pitching Matchup: Cam Schlittler (5.06 ERA) VS Max Scherzer (4.70 ERA)

Los Angeles Angels (+148) @ New York Mets (-190):

Spread: New York Mets -1.5 Over/Under: 9.0

Pitching Matchup: Kyle Hendricks (4.88 ERA) VS Frankie Montas (5.03 ERA)

San Francisco Giants (+185) @ Atlanta Braves (-120):

Spread: San Francisco Giants -1.5 Over/Under: 9.5

Pitching Matchup: Landen Roupp (3.27 ERA) VS Davis Daniel (1.80 ERA)

Chicago White Sox (+190) @ Tampa Bay Rays (-245):

Spread: Tampa Bay Rays -1.5 Over/Under: 8.5

Pitching Matchup: TBD VS Drew Rasmussen (2.86 ERA)

Athletics (+188) @ Texas Rangers (-230):

Spread: Texas Rangers -1.5 Over/Under: 7.5

Pitching Matchup: J.T. Ginn (4.91 ERA) VS Jacob deGrom (2.32 ERA)

Kansas City Royals (+195) @ Chicago Cubs (-250):

Spread: Chicago Cubs -1.5 Over/Under: 9.0

Pitching Matchup: Rich Hill (4.01 Career ERA) VS Matthew Boyd (2.34 ERA)

St. Louis Cardinals (-155) @ Colorado Rockies (+123):

Spread: St. Louis Cardinals -1.5 Over/Under: 12

Pitching Matchup: Erick Fedde (4.83 ERA) VS Bradley Ballock (9.97 ERA)

Houston Astros (-127) @ Arizona Diamondbacks (+102):

Spread: Houston Astros -1.5 Over/Under: 8.5

Pitching Matchup: Framber Valdez (2.75 ERA) VS Eduardo Rodriguez (5.94 ERA)

Milwaukee Brewers (+100) @ Seattle Mariners (-122):

Spread: Milwaukee Brewers -1.5 Over/Under: 6.5

Pitching Matchup: Jacob Misiorowski (2.81 ERA) VS Logan Gilbert (3.39 ERA)

Minnesota Twins (+188) @ Los Angeles Dodgers (-240):

Spread: Los Angeles Dodgers -1.5 Over/Under: 8.5

Pitching Matchup: Simeon Woods Richardson (3.95 ERA) VS Yoshinobu Yamamoto (2.59 ERA)