Today in the MLB: July 21, 2025 Best Bets, Odds, Lines, and More

Baltimore Orioles (+120) @ Cleveland Guardians (-148):

Spread: Cleveland Guardians -1.5 Over/Under: 8.0

Pitching Matchup: Tomoyuki Sugano (4.44 ERA) VS Tanner Bibee (4.29 ERA)

Detroit Tigers (+112) @ Pittsburgh Pirates (-139):

Spread: Pittsburgh Pirates -1.5 Over/Under:7.0

Pitching Matchup: Jack Flaherty (4.65 ERA) VS Paul Skenes (2.01 ERA) 

San Diego Padres (+120) @ Miami Marlins (-148):

Spread: Miami Marlins -1.5 Over/Under: 8.5

Pitching Matchup: Randy Vásquez (3.80 ERA) VS Eury Pérez (3.18 ERA)

Boston Red Sox (+180) @ Philadelphia Phillies (-245):

Spread: Philadelphia Phillies -1.5 Over/Under: 8.5

Pitching Matchup: Walker Buehler (6.12 ERA) VS Zack Wheeler (2.36 ERA)

Cincinnati Reds (-139) @ Washington Nationals (+112):

Spread: Cincinnati Reds -1.5 Over/Under: 9.0

Pitching Matchup: Brady Singer (4.32 ERA) VS Jake Irvin (4.58 ERA)

New York Yankees (-129) @ Toronto Blue Jays (+102):

Spread: New York Yankees -1.5 Over/Under: 8.5

Pitching Matchup: Carlos Rodón (3.08 ERA) VS Kevin Gausman (4.19 ERA)

Los Angeles Angels (+115) @ New York Mets (-205):

Spread: New York Mets -1.5 Over/Under: 8.5

Pitching Matchup: Tyler Anderson (4.34 ERA) VS Kodai Senga (1.39 ERA)

San Francisco Giants (+110) @ Atlanta Braves (-137):

Spread: Atlanta Braves -1.5 Over/Under: 9.5

Pitching Matchup: Hayden Birdsong (4.11 ERA) VS Bryce Elder (5.65 ERA)

Chicago White Sox (+190) @ Tampa Bay Rays (-250):

Spread: Tampa Bay Rays -1.5 Over/Under: 9.0

Pitching Matchup: Sean Burke (4.36 ERA) VS Shane Baz (4.17 ERA) 

Athletics (+104) @ Texas Rangers (-129):

Spread: Texas Rangers -1.5 Over/Under: 8.5

Pitching Matchup: Jacob Lopez (4.20 ERA) VS Jack Leiter (4.37 ERA)

Kansas City Royals (+123) @ Chicago Cubs (-152):

Spread: Chicago Cubs -1.5 Over/Under: 7.5

Pitching Matchup: Noah Cameron (2.31 ERA) VS Ryan Brasier (1.04 ERA)

St. Louis Cardinals (-157) @ Colorado Rockies (+125):

Spread: St. Louis Cardinals -1.5 Over/Under: 11.5

Pitching Matchup: Michael McGreevy (4.22 ERA) VS Austin Gomber (5.635 ERA)

Houston Astros (+125) @ Arizona Diamondbacks (-155):

Spread: Arizona Diamondbacks -1.5 Over/Under: 9.0

Pitching Matchup: Colton Gordon (4.67 ERA) VS Zac Gallen (5.40 ERA)

Milwaukee Brewers (+105) @ Seattle Mariners (-130):

Spread: Seattle Mariners -1.5 Over/Under: 7.0

Pitching Matchup: Bradon Woodruff (2.61 ERA) VS George Kirby (4.50 ERA)

Minnesota Twins (+143) @ Los Angeles Dodgers (-190):

Spread: Los Angeles Dodgers -1.5 Over/Under: 9.0

Pitching Matchup: David Festa (5.25 ERA) VS Shohei Ohtani (1.00 ERA)